If thats what you have, use it. Keep your shots to 100 yards or your comfortable range and it will work great. I keep mine to 75 yards. Mine is just not as accurate as my centerfires. Its almost dead on out 75 yards so no worries of compensating drop on little fox vitals. We can only use rimfire here. We don't have many yotes here but I wouldn't hesitate to use the 22 mag. Just make sure you use a jacketed hollow point.