Well and I am just the opposite of many here. I unload my rifles every night. I walk back to the house, and blast into the bullet trap. I then clean them and reload fresh in the morning. Then I know that the rifle will go off.
Many years back, I had left a Renegade loaded for a couple days in season. It was second to the last day, and I had not seen a deer all season. Finally a small buck stepped out. It was legal and I like venison. I took aim and "click- snap" the cap went off but the main charge did not. I re-capped. "click-snap" same thing. Well the deer did not hang around as third time might be a charm.
I pulled the nipple packed a little powder under the cap, reset the nipple and capped. "BOOM" with just a hint of hangfire. That was the last time I let a Renegade sit with a charge, that I was going to depend on for hunting. I would have swore under oath that there was no way that charge could be contaminated. I was of course wrong (which is not uncommon to me). I have played with the rifles since them to see if I can make them fail. Sometimes they do, sometimes they don't. So I don't play for odds when it means meat in the freezer.
I have also had inlines fail. I had a T/C Black Diamond fail, with a 209 primer. I was kind of shocked actually. All my rifles were brought in from the cold (and in northern Wisconsin in December we mean cold) and put into the wood working shop which is unheated. They sat muzzle end down on a towel in a corner, and the shop locked.
This winter I am going to do some extensive testing with rifles to see what or how to make them fail. It will give me something to do.
Also I might add this to your question. If I were hunting with a powder that does not cause corrosion quickly, and seems to be sensitive to the amount of fire from a primer... why would I NOT shoot it off, and then load fresh in the morning. Its not like you would have to clean the rifle each night. I would think you could shoot it off, swab it with solvent and a dry patch, load fresh in the morning, and do that all season long. Or perhaps a few days, then clean it some night. I like a fresh load...