I think some calibers have an "optimum" bullet weight that works better than others, and that is assuming you are using it for deer. I've used a 270 for 35 + years and 130 grain is a great choice for deer. My rifle happens to like Remington ammunition so I stick with it. I have other rifles in other calibers that shoot like crap with Remington ammo. Those rifles do better with Hornady or Fedreal ammo.