This reminds me of the debate I hear every year at black bear camp. .30-30, .270, .308, .30-06, 300 Win Mag ......
I have never been very loyal to any caliber, make of vehicle or even manufacturer of rifle. I try different ones
when I can with the limited income that I have. Family needs come first and my toys a distant 5th.
For PA whitetail deer, I have used .50 cal and .45 cal inlines and there was no difference in the results - a freezer
full of venison. Although .50 cal is very common, it is by no means the minimum. I plan to use a .45 Knight Elite
this year and I won't feel under gunned.
Pick something that will work for you and be gracious in accepting what others choose to use.