Driftrider, I' ve lost count of how many coyotes I' ve taken with my 22-250 and honestly, I' ve shot them with about every bullet on the market. I' ve always used 50 gr. bullets and have tried hollow points, which almost always went all the way through and left large exit wounds, then tried the V-max bullets, also 50 gr., and they usually went all the way through too, also leaving large exit wounds, so I decided that for the most part, I will have two holes and am now using 50 gr. psp, they also usually go all the way through, ,but usually the exit wound is managable. I usually am taking shots well with-in 100 yrds., so if you could take longer shots, that would help as far as not leaving two holes. I haven' t tried the 40 gr. V-max, I suspect that it might be worth while to check into as far as not leaving two holes in the hide, but I just don' t know if you hit a shoulder if it will penetrate enough or not. The other thing I like to do, which I' m not always able to control, is to take frontal shots. That is my favorite shot, only one hole and it drops them faster than any other hit.