I aim a little under halfway up right at the shoulder crease. I usually don't have deer drop on the spot to much but rarely do they go more than 40 yards. Plus, I rarely ruin any meat at all. I low lunged a doe this year and she made it about 100 yards in an open Bean field but that is the longest Ive had one go on me. Ive seen articles and pictures that say more of the vitals are located in front of the shoulder crease than behind, but Ive been aiming at the crease since I started hunting and it hasn't failed me yet!