I used both this deer season. 100 gr. sierra gk and H414 out of savage .243, took a 105 lb doe at 150 yds, broke down far should. She went about 10 yds. 105 gr speer and imr4831 out of 6mm-06, took a 150 lb. buck quartering to me at 175 yds. drt, no exit.

I've had good terminal results with both. Most guns shoot the 100 gr gk well. Some are picky with the speers.