I have never owned a 30-06 that would not shoot either the Sierra 165 grain bullet, or the Nosler 165 grain BT well. I always try the Sierra first(because of price). I only have one 30-06 that shoots the Nosler a bit better. I also prefer RL22 powder. I get the best velocities from RL 22. And as stated above it is idiot proof powder. You could dip the case full and not have a pressure problem. So it is a very safe powder, and it performs very well. Tom.