Cold weather can be tough, but I have always done good when it is Cold. The wind is a different story though.
I killed my 1st buck, a 9 point when it was 5 below zero. Hunting temps likeI did last week in NE though was a different ball game. It tested my determination to hunt when the temps stayed below zero all day and dipped to 20 below and even lower one night.
When bad weather rolls through they may hold tight for a day, but then they'll be on the feed, and move as little as possible. IMO you are as likely to find them feeding midday as the normal early morning, late evening routine.

Dan