I started Yote hunting 3 years ago. I went out and bought me a Kimber 84M Longmaster VT (.22-250) topped with a Zeiss Conquest 4.5x14X44mm. The rifle was a beauty and very accurate. However, I quickly got tired of carrying around a 10lb rifle and more importantly, I wanted something I could confidently shoot a deer (200+ yards) with when yote hunting in the fall. I sold my beautiful Kimber and bought a 6lb Remington 700 Mountain Rifle in .243 and kept the Zeiss scope for it. Wow - this is a great set-up. I can shoot .55gr ballistic tips at over 4,000 fps or 100gr at larger game. I can carry it all day and never get tired.

I'd recommend the .243, which can do everything the .22-250 can and more.