RE: 245 grain vs 295 grain bullets?
Some can probably guess what I'm going to say.............try FPBs.
They are similar to a PB in that they are full bore size, no sabot needed. They have a thicker jackt than PB, and are not supposed to fragment. The Hornady site indicates great terminal performance between 800 and 200 fps. Only one weight right now, 350 gr (heavy is good).
The site also indicates you can get almost 1500 fps with 130 gr of powder, as I recall. That is a 150 yd load (2.75 high at 75, zero at 125, 3.5 low at 150) that will just wilt a deer. I'm shooting 100 gr now, but over the summer I'll mess with it to see what a heavier charge will do for accuracy. Right now I'm 2" high at 50, good to 125 wit a center of mass POA.