Yes, it's true - nearly any big-game caliber has the potential to produce bloodshot tissue.

I've actually waited a long time for someone to ask whether a .300 WM (et al) is "too much for deer". I thought everyone needed those .300s to make the 7000-yard miracle shots?

My .243 with a 100 gr bullet does about as much damage as my .30-06 does with 150s. Step the .30-06 up to 190 grains though, slowing it down a couple hundred fps, and it's just as effective, though not quite so destructive.