LOL....well, other than the obvious difference, having only 1 pin.......The biggest is getting used to moving that pin instead of just using a different one. It takes a little getting used to, but once you do, you'll never go back. No more confusion, no more using the wrong pin, no more cluttered sight picture......No more playing the gap......Set that pin for the exact yardage and let fly.
What I do for hunting is leave my pin set @ 27 yards. I am 1 1/2" high at 20 yards and 1 1/2" low at 30 yards. For a deer, who cares about an inch or so. As long as the deer is 30 yards or closer, I hold center mass and let it eat. Gets 'em everytime.