How much do your arrows weigh? What kind of speed are you getting from your bow?

My bow is at 43lbs. I have just under 40 foot pounds of energy. I have a 26" draw (or 25.5" can't remember).
I use 125 grain, 3 blade muzzys with 1 3/16" cutting diameter. My total arrow weight is 368 grains.

My arrow passes completely through most every deer I shoot.

If I had to guess, I'd say you're arrows are not flying straight or they are way too light.