RE: Just watched a Hunting show Ruger 375
OEH - I didn't see that one but I think it not only has to do with shot placement, but also with the timing of the shot in relation to the heart beat.
I watched a video of my cousin shooting a brown bear with a 375 H&H. That bear took 3 direct hits - first and third one into the left shoulder and the second one into the right shoulder before going down - and a fourth round to finish him.
Then again, I've seen them crumble with one shot from a lesser round.