I shot a doe last year at 368 yards with a 243 cal. rem. 700,she ran about 50 yards and fell over.Killed a 9 pointer a few years ago at about 100 yards with a 243 he feild dressed 217lbs and fell within 10 feet of where he was shot,the 100 grain bullet broke both shoulders and left a large exit hole,but he was at close range.I would shoot him with which ever gun I shot the best with and felt comfortable with.