The answers are probably as limitless as the types of bullets and powders out there. If it was me i would use about a 100 grains of powder with a 250 to 300 grain saboted bullet with a good BCE ( ballistic co-efficient) Most companies offer that info on the package or their website.Something like the Shockwave,Scorpion Gold,Precision rifles dead center,CVA's slick load etc, . Most of the times it boils down to finding what works best in that particular gun. They each seem to have a preference all their own. The only way to find that out is to spend time shooting different loads till you find the perfect one. What inline are you getting??