I have a Black Diamond XR in .50 caliber and mine is one that shoots about anything I want to put down it. As for the 110 grains you want, if 100 does it, I would not get concerned about 10 grains of powder.

For large game I would be shooting a 250 grain Shockwave with 100 grains of Pyrodex RS powder. Another large game load is a 375 grain Buffalo Bullet SSB with 110 grains of Triple Se7en 2f.

For just plinking and having fun, I shoot about anything on the shelf.

How old is your powder?
Ever try pellets? *Mine shot 150 grains of pellets with a shockwave real well.
Are you swabbing the bore between shots? If not, that's your problem.
What primer are you shooting?
Is your barrel floating?

Other then that, my Black Diamond XR is a boring rifle as I load it and it shoots right were it always did.

Start your load work at 90 grains of loose powder and work up from there. I use Triple Se7en and Pyrodex RS for best results. When you get a tight group, then start pushing it until it falls out.