RE: Best self defense pistol
I' d stay away from the Glock and other autos. I have several Glocks, but I don' t think they are the best for your situation. Take a look at a medium framed 357 Mag. with about a 4" barrel. You can load it with 38 specials for your wife or you can load it up with 357 magnums for hunting or more powerful self defence loads. A revolver is much easier to operate for the average person.