The greatest distance I've taken a deer was 30 yards with a PSE Firestorm Lite and a 75 grain muzzy. I shoot about 305 fps and practice shooting at a dime at 20 yards taped to a 3D. It's all about getting close. Most of my shots are from 10 feet to 20 yards. I'd never consider taking a long shot for fear of just wounding the deer, I wouldn't think that being much of a sportsman.
Jim