I have a 243 that has proven to be deadly on both, but I did just get the 25-06 and am hoping this will take the place of the 243 (the wife has claimed the 243). I really like the 25-06 round and the numbers are real similar on both rounds. I just have always wanted a 25-06 and took the plunge...Still breaking it in but it is proving to be a shooter....Good Luck on your decision