.243 is a great all around round for deer down to ground squirrels, and a great coyote round. Just use the appropriate bullet for the task at hand. For deer I use 100 grain corelocks or 95 grain partitions. For varmints I like the 70 grain nosler ballistic tip. For yotes, it depends if you want to keep you hides, or blow big holes. For hide hunting use a solid bullet that will make a little hole in and out, for absolute destruction the 70 grain tnt hollow point will turn them inside out.