As far as deer running off at big distances. I've been startled a time or two by a shot close by. Ones way out I never even move. I think similar holds true to deer. I've seen deer spook at the shot and take off running at close range. I've also seen deer shot with a quiet bow and the deer hardly moves until it falls over.

I think the sound makes a big difference in a deer running off. In most cases anyway. Just an opinion like everyone elses. I have no knowlege first hand of long range shots but it seems to make some sence.

I wish I could afford a rifle that shot that well at those distances. And I wish I had the place to practice. And maybe even hunt. But I think my farthest shot ever was about 80 yards. Not that I haven't past up farther shots. I just like getting close. If you can without wounding or losing animals ...go for it.