I can't speak for the vanguard, but I can speak for the caliber. The .22-250 and it is an incredible round. I shoot a Kimber LongMaster VT in .22-250. It is the most accurate combination (rifle /round)I've every owned. If your looking to keep the pelts on anything smaller than coyote, you may want the .223. There isn't much left of varmits.