i have a savage 12 in 22-250 and love it to death. it is poison on coyotes with a 55gr nosler ballistic tip at around 3600fps. personaly i wouldnt use it for anything larger than coyotes unless you use a good premium bullet such as the speer trophy bonded bear claw or the nosler partition. and more importantly than that you have precise shot placement. but even then you more than likely wont get a pass through and will have a very scant blood trail, if you even have one. thats just my .02 worth.