.22-250 is awesome! perfect for coyotes on down.....IMO there are only 2 .223 caliber cartridges to consider.....the .22-250 being awesome and popular, the other the .220 swift just being even more awesome! yet not so readily available. I've yet to see anyone own a .220swift and say anything bad about the caliber, maybe barrel burner, but I think that was in the past....moreso.

personally I like 4000fps.....but whatever shoots best in your gun use.....I think anything from 40-50gr is ideal for a .22-250, though some guys love the heavier bullets, 75gr......I know theyd buck the wind better, but then I think why not shoot something like a .243 at that point, I know I know ballistic coefficient etc....but still.

If you're considering a .22-250 you may really want to take/consider the CZ500 Varmint Kevlar....I know I am! Probably not much of a price difference either.