Read and follow all the instructions including the general loading information in the reloading book you buy for the bullets you use (e.g. Hornady, Nosler, Speer, etc.)
I personally start on the lower end of the minimum recommendation, but not the lowest. I use the recommended primers for the loads the bullet mfg says, then examine the cases carefully as your reloading handbook tells you what warning signs indicate potential trouble, carefully working up to the higher end staying strictly within the recommended limits only!!
I don't load up to the maximum recommended charges. This has worked for me.