I rifle hunt with a 30-06 150 gr bullets. I shot a 210# buck 4 years ago. the first bullet hit him facing me in the center of the brisket. He ran about 30 yds and stopped. I walked closer and could see his head and front shoulders. I shot him again behind the front shoulder. I later found out he was quartering away hard. The bullet entered just in front of the hind quarter and traveled forward thru the guts. He didn't even flinch! I circled around and assumed he must be hung up on something. When I got broadside to him I realized he was just standing there. I shot him again broadside thru the lungs and he took off running. He went about 50 yds and layed down. He was just sitting there looking around. I walked up to within a few feet and he jumped up and ran again! He went about 30 yds and layed down again. This time he was too sick to get up. If this didn't happen to me I don't think I would believe it. They can be tough critters!
PS I switched to premium loads