For sighting in - I usually mount the scope and then take it down to the local gun store - they bore-sight it for $3.

After it is bore-sighted, I'll go to the range. A bore-sighted rifle should (in theory) print shots on the paper at 100 yards. So from there, you start to work up loads - experimenting with powder charges and bullets until you find something that shoots accurate groups. Once you get there, you adjust the scope to center your shots on the bulls-eye.

For typical WV ranges, I would sight it to be dead-on at 100 yards with whatever load you work up.