As said bullet placement is the key, allot of practice an know how your gun shoots. I shoot a 10/22 tricked out an I know where I shoot at 100yds in the right conditions, 22lr is not an ideal 100yd gun on animals, I've never shot one past 60yds with my 10/22 and the head shot just makes them drop never had one run. I stepped up an us a 22wrm now and still all have been under 100yds but I've passed on several becuase of not offering the ideal head shot or just to far. Got to know your limits an the guns.