I agree with bowfisher you will definately lose some,if you have any centerfire rifles or a shotgun and some #4 buckshot I would use either before the 22,I killed one that walked into range (a yearling)one year squirrel hunting at 40 yards with a 22lr,neck shot,but I have lost a couple more that were 50-60yard head shots that I saw run over several feilds and hollows,never to be found.So use enough gun to kill'em cleanly,I know it's a lowly coyote but I dont want any animal to die a slow,painful death with no chance of recovery,some people swear by the 22lr as being an efficent predator hunting caliber and it may be for them,but if you count what you kill cleanly with one shot and count what you have to shoot several times or it gets away and you dont find it,I'm sure that the get aways and several shooters will be a lot more than the one shot kills.I have only shot coyotes with a 22 by chance encounters,I have never carried any rifle that small to call in coyotes.