I use MPBR myself but in a ML I find it almost useless as the wind plays more havoc with the bullet trajectory due to the low BC's, so the theory doesn't always apply...if that makes sense???
Instead I set up my zero for what I see the majority of the time hunting,in most cases its a150 yardzero for my ML's. I then just practice shooting and learning where I need to hold over or adjust to obtain zero/targetfor ranges beyond 150 yards. This method has worked very well for mewith both ML's and CF's.