Thought I'd mention, maybe I'm wrong and dangerous game isn't everywhere in africa....but I suspect there's always a chance of running into something big and mean and willing to eat you. Sure the guide should have a gun/backup, but personally, he's welcome to help shoot that beast when he charges, but I'm also going to be killing a rifle that would be adequate to kill somethign big. Personally I don't see ever bringing a .270 or .30-06 to africa, smallest to me would be .300 win mag, or .340 wby mag.

My cousin a few years back went to africa and fell in love with his .375h&H, even though he had another rifle or two to use, he used his 375 on everything, and personally if a lion comes by id much rather have a .375 than a 300 win mag, and way more so than a .270. Somethign to consider.....also a 300 win mag or 338 mag on leopard sounds nice, as well as kudu

My vote would probably be for anything .300 mag-375