Balistic reticles work the same as using hold over, they just give you convenient points of reference with the extra aiming points. The way I set my ballistic scopes up is to first find an accurate load and chrono it, then run a ballistic chart to see what it should be doing. I compare that to what the graduations of the aiming points of the reticle are,then determine the distances at which the load matches the reticles setup. I then go out and confirm at the range that the calculations are correct and fine tune from there. Some loads can work at the distances listed for the omega if you adjust the 100 yard zero up a little, maybe an inch or so. Once you confirm and fine tune the sight in, make a chart of what distances the aiming marks are good for and tape it to your stock and memorize it so you are ready when the time comes. Good luck.