I have tested this while practicing and found that canting the bow made me shoot several inches off either side. Up and down was still fine. I think as far as hunting goes you would still be lethal as long as you aimed in the right spot to begin with. If you aimed too far back and canted the bow, then your wounding odds increase of course. just what i have seen. If you are missing more than 3-4" it prolly has nothing to do with canting the bow a little. JMO.