Have you considered ............
I see lots of questions posted in here like "Have I got enough gun , I can only shoot a 300grn bangwhamer uber slug with 80 grs of FFG in my 45 whats it ".
It makes me nuts some times . The 45-70 has slain man and beast in every field with a lil sissy 350-500 grn bullet soundering allong at a measly 1800fps (only in the last 60-70yrs hopped up to a blistering 2000-2200fps) propelled by less in some cases alot less than 70grs of FFG . And that hot rod the 45 Colts launches a 250 at 850fps with a paltry 37grs and is considered a 50+ yrd deer slayer.
Now I know that a cartrige is "cheating a little" but aren't all these 209 inlines a closed sealed breach?
I just saw a new .45 magnum ,the builder escapes me ,that is rated for 3 50 grn pellets and a 250grn bullet . The 45-110-500 aka "the Quigley gun" matches the 458 Win mag . The above load would be about a 45-150-250 and that pushes the realm of the 460 Weatherby .
Just seems to me that the purety of the front stuffer is lost at some point and/or we've lost sight of just how little it takes to "cleanly and humanly harvest" an animal we intend to eat .