Bigger & better? 22=250, inasmuch as you get a little more range, and less wind drift for awhile as it is more hyper. Bigger kaboom too. I have used either a 223 or 222 Rem as I don't need to shoot over 200, and it is quieter in our settled areas. If I lived in the Nebraska flats or Montana, it would be the 22 250 for me.