A scope is a scope. The main reticule intersection of a X bow scope will work as an aiming device for a 22. The secondary aiming points will also work, their accuracy will depend on distance. Given tht the trajectory of a 22 is substantially flatter than that of a bolt the secondary aimpoint will be "on target" much further out. And, given the low magnification of most said scopes, they may be largely useless for distance shots.