I've killed a half a dozen with mine and have been really impressed; it's definately an improvement over the small calibersfor my application. There will be some sizable holes if you use the factory ammo offerings (Ballistic Tips) but I'm looking forward to developing a hollowpoint in the near future.
Here's a clip that shows the common reaction of a coyote to the 25wssm pushing a 90 grainer.
http://smg.photobucket.com/albums/v291/jrbhunter/Predators/?action=view&current=NoseyFlop.flv