I used to use (and still own) a redhawk in .44 mag with a 2x scope.
Although I killed a few deer and hogs with it I could never reach the level of accuracy with it I was after so I now use a Savage Striker in .308 topped with a burris 2x7 scope. I LOVE this gun.

I know this is more of a hand rifle than a pistol, but I owed it to my quarry to use something I could shoot accurately on a consistant basis. So far it has 2 bucks to its name and looking for more .