That all depends on what loads you use and how far you want to shoot.

If you use 150 grn silvertips by Winchester sighting in 3 inches high at 100 yards would put your aproximate zero at 250 yards. Leaving you around 3.5 inches high at 150 yards and 4 inches or so low at 300 yards.

This is with your sight 1.5 inches above the bore.

If you sighted in for 100 yards you would be pretty flat out to 100 yards, 1 inch low at 150 yards and 3.5 inches low at 200 yards.

This is on paper anyway, the only way to really know is to shoot YOUR gun at those distances and see what it does.

If you have no intentions of shooting beyond 200 yards I would just go with a zero at 100 yards for simplicities sake. If you think you want to shoot farther you might want to pick a different zero range.

If you shoot a different cartridge this will change as well.

Paul