My Traditions Pursuit Pro has a cross-bolt safety in the trigger guard. If I remember right it can't be cocked with the safety ON and if cocked it can't be fired with the safety ON. I never carry it with the safety on since I carry it with the hammer down. I would say it would be safe to cock it and then put the cross-bolt safety ON once in the stand or blind. Not really any different than havinga "hammerless" design gun with a cross-bolt type safety, except you can visually see the hammer.