RE: .280 Remington
if you handload, try 56.5-57 grains of IMR 4350 behind a 140 grain bullet. I'm getting .75" groups at 100 yards with that load since I bought the gun at the age of 16 in 1990. Comes out of the muzzle around 2970-3000 fps. I've flipped whitetails over out to 450yds with that load. I'd shoot 160 for elk though, as most guys will tell you that. But I think a 140 gr Barnes TSX or Accubond will do just fine, and I wouldn't be afraid to tote that combo with me.