ORIGINAL: woofer
Shoot them in the head that way you want ruin any meat....
I killed one with a .22 while fishing shot him right between the eyes..You have enough gun and if its on go forthe head shot...
Really, it is shoot them in the head, so you don't have to chase them into a thicket.
I had a Marlin 1895GS guide gun for a while and had super results with the Hornady LeverEvolution 325 gr ammo. As good as they shot out of my gun and reports that I have read from others, I could never justify the load development process for a 45-70.