I think like the rest. The 22 LR is not enough, but if you have nothing else then equip it with CCI Stingers. Keep your range close and try to shoot them in the head. If you shoot them through the lungs they will usually go 100-200 yards before lying down. Coyotes are very tough to kill sometimes. We had one that came between three of us that got 12 22 LR Hollow Points in the head, and three 20 ga. shotgun blasts with #4 buck all at 20 yds or less before he finally died. I like the 243 in 100 gr. Remingtons. You anchor him in the front shoulder and he is going no where.