I wouldn't try it. I've made good hits on fox with 22mag, and had them run a long way. And one of the biggest problems is the 22lr and 22mag don't make a big enough hole to allow good blood trail. There is no doubt that a 22lr will kill a yote, I have heard stories of deer being taken with this round at close range. I agree with Howler, 223 is caliber of choice.