I don't think it will make much difference at the ranges your talking about. Even going to 200 yards theres not enough difference in drop to worry about. Theres not that much difference in the point blank range of the two bullets, less than 5 to 10 yards.

I prefer the 300 for long range due to the retained energy being about 200 to 300 foot pounds higher and the difference in drop at 200 yards only being about 1". The higher BC of the 300 makes up somewhat for the small amount of velocity loss.