I've yet to shoot a deer with a Gold Dot but my theory is when possible, bigger is better. I like to throw lead. The bigger projectile will of course have a lower velocity, but at close ranges it should not really make much of a difference. The heavier projectile should carry more energy, and should penetrate better, although I would guess that the 250 would have little trouble either. So I would suggest in your case that what ever of the two shoots the most accurate group is the one I would use.