Rammers right, put the bullet in the right place, and this whole discussion is moot. I have never found anything in North America that wouldn't fall to a well placed 180 grain bullet out of my .30-06. But hit an elk in the hind quarters with a .338 and we will see how good your wind is blood trailing it into the next county. The .270 WSM with any premium higher sectional density bullet, will work great if it shoots accurately out of your rifle.