i dont think that a .22 would kill a yote if you shot it in the vitals. that being said, if you were to shoot it in its head, it would drop. as for all of my varmint and predator hunting, (armadillos, coyotes, and foxes) i use my .223 winchester JHP rounds. VERY DEADLY. my buddy craig uses his .22-250 and it does a number on yotes as well.